Matthew T. Loch

Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links

Conor M. Haney, Matthew T. Loch, W. Seth Horne · Chemical Communications · 2011 · 80 citations

Biochemistry, Protein Assembly, Protein Folding +14

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Julie L. Engers, Alice L. Rodriguez, Leah C. Konkol et al. · Journal of Medicinal Chemistry · 2015 · 67 citations · Full text

Therapeutic Potential, Neurotransmitter, Immunology +20

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu_2/4 Heteromers

Colleen M. Niswender, Carrie K. Jones, Xin Lin et al. · ACS Chemical Neuroscience · 2016 · 58 citations · Full text

Discovery of VU6005649, a CNS Penetrant mGlu_7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-<i>a</i>]pyrimidines

Masahito Abe, Mabel Seto, Rocco G. Gogliotti et al. · ACS Medicinal Chemistry Letters · 2017 · 33 citations · Full text

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1<i>H</i>-Pyrazolo[4,3-<i>b</i>]pyridin-3-yl)amino)-benzo[<i>d</i>]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu₄)

Sean R. Bollinger, Darren W. Engers, Joseph D. Panarese et al. · Journal of Medicinal Chemistry · 2018 · 25 citations · Full text