mGlu ₇ potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Rocco G. Gogliotti, Rebecca K. Senter, Nicole M. Fisher, +12

Science Translational Medicine

mGlu₅positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Rocco G. Gogliotti, Rebecca K. Senter, Jerri M. Rook, +11

Human Molecular Genetics

Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress

Max E. Joffe, Chiaki I. Santiago, Branden J. Stansley, +6

Neuropharmacology

Synaptic PlasticityNeuropsychologyStress HormonePsychiatryBrain Function +12

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Shalini Dogra, Branden J. Stansley, Zixiu Xiang, +7

Biological Psychiatry

Cognitive ScienceNeuropsychologyPsychiatryBrain FunctionMedicine +7

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target

Rocco G. Gogliotti, Nicole M. Fisher, Branden J. Stansley, +4

Journal of Pharmacology and Experimental Therapeutics

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia

Ranjani Ponnazhagan, Ashley S. Harms, Aaron D. Thome, +5

Journal of Neuroimmune Pharmacology

InflammationPrimary MicrogliaAnti-inflammatoryAutoimmune DiseaseMedicine +7

Discovery of VU6005649, a CNS Penetrant mGlu_7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-<i>a</i>]pyrimidines

Masahito Abe, Mabel Seto, Rocco G. Gogliotti, +14

ACS Medicinal Chemistry Letters

Phenotypic profiling of <scp>mGlu₇</scp> knockout mice reveals new implications for neurodevelopmental disorders

Nicole M. Fisher, Robert W. Gould, Rocco G. Gogliotti, +11

Genes Brain & Behavior

A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes

Nicole M. Fisher, Aqeela AlHashim, Aditi Buch, +10

JCI Insight

Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5

Branden J. Stansley, Nicole M. Fisher, Rocco G. Gogliotti, +3

Cerebral Cortex

Synaptic PlasticityCognitive ScienceNeurobiological MechanismPsychiatryMedicine +13