Céline Duquenne

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

Michael T. McCabe, Heidi M. Ott, Gopinath Ganji et al. · Nature · 2012 · 1.8K citations

Ezh2 Inhibition, Lymphoid Neoplasia, Hematological Malignancy +10

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Sharad K. Verma, Xinrong Tian, Louis V. LaFrance et al. · ACS Medicinal Chemistry Letters · 2012 · 373 citations · Full text

Histone Modifications, Drug Discovery Program, Engineering +18

Novel applications of convertible isonitriles for the synthesis of mono and bicyclic γ-lactams via a UDC strategy

Christopher Hulme, Liang Ma, Marie-Pierre Cherrier et al. · Tetrahedron Letters · 2000 · 60 citations

Enantioselective Synthesis, Convertible Isonitriles, Organic Chemistry +6

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 2. Rational Design of Naphtho[1,2-<i>d</i>]imidazole Thrombopoietin Mimics

Kevin J. Duffy, Alan T. Price, Evelyne Delorme et al. · Journal of Medicinal Chemistry · 2002 · 59 citations

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

Jesús R. Medina, Christopher Becker, Charles W. Blackledge et al. · Journal of Medicinal Chemistry · 2011 · 53 citations · Full text

Drug Target, Chemoprevention Strategy, Chemical Biology +20