Concepedia

Motoko Hosono

MH

Statistics

Publications

12

Citations

352

H-Index

11

Active since

1991

Affiliations

Futaba (Japan)(Current)

Shionogi (Japan)

Osaka City University

Hokkaido University

Janssen (Belgium)

Motoko Hosono is an author at Futaba (Japan) specializing in pharmacology, enzyme inhibition, and medicine.

Publications per year

1991–2018

12

Publications

12

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice<sup>2</sup>

Kouhei Nishitomi, Gaku Sakaguchi, Yuko Horikoshi et al. · Journal of Neurochemistry · 2006 · 98 citations · Full text

, , +17

Conformational Restriction Approach to β-Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode

Shuji Yonezawa, Takahiko Yamamoto, Hidekuni Yamakawa et al. · Journal of Medicinal Chemistry · 2012 · 51 citations · Full text

, , +17

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui et al. · Journal of Medicinal Chemistry · 2018 · 34 citations · Full text

, , +17

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano et al. · Journal of Medicinal Chemistry · 2018 · 34 citations · Full text

, , +17

Renal Pelvic Carcinoma which Shows Metastatic Potential to Distant Organs, Induced by N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine in NON/Shi Mice

Takashi Murai, Satoru Mori, Motoko Hosono et al. · Japanese Journal of Cancer Research · 1991 · 29 citations

, , +10

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