Gaku Sakaguchi

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease

Ryo Kimura, Kouzin Kamino, Mitsuko L. Yamamoto et al. · Human Molecular Genetics · 2006 · 268 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Physical and Functional Interactions of Doc2 and Munc13 in Ca2+-dependent Exocytotic Machinery

Satoshi Orita, Akira Naito, Gaku Sakaguchi et al. · Journal of Biological Chemistry · 1997 · 136 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice²

Kouhei Nishitomi, Gaku Sakaguchi, Yuko Horikoshi et al. · Journal of Neurochemistry · 2006 · 98 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Interleukin‐1β up‐regulates TACE to enhance α‐cleavage of APP in neurons: resulting decrease in Aβ production

Yuriko Tachida, Kazuhiro Nakagawa, Takashi Saito et al. · Journal of Neurochemistry · 2007 · 90 citations

Life Sciences, Neurobiology, Neuroscience +17

Development of Aβ terminal end-specific antibodies and sensitive ELISA for Aβ variant

Yuko Horikoshi, Gaku Sakaguchi, Amanda G. Becker et al. · Biochemical and Biophysical Research Communications · 2004 · 87 citations

Pharmacy, Biotechnology, Molecular Biology +16