Karl P. Hodel

Comprehensive Analysis of Hypermutation in Human Cancer

Brittany Campbell, Nicholas Light, David Fabrizio et al. · Cell · 2017 · 772 citations · Full text

Somatic Variant, Cancer Genomics, Comprehensive Analysis +5

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Adam Shlien, Brittany Campbell, Richard de Borja et al. · Nature Genetics · 2015 · 372 citations · Full text

Genome Instability, Somatic Variant, Somatic Mutations +9

DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells

Jiil Chung, Yosef E. Maruvka, Sumedha Sudhaman et al. · Cancer Discovery · 2020 · 84 citations · Full text

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status

Karl P. Hodel, Meijuan J.S. Sun, Nathan Ungerleider et al. · Molecular Cell · 2020 · 69 citations · Full text

Biology, Genome Instability, Allelic Variant +12

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Karl P. Hodel, Richard de Borja, Erin E. Henninger et al. · eLife · 2018 · 39 citations · Full text

Engineering, Cancer Pathology, Genetics +19