Susan Cornell-Kennon

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Andrew L. Kung, Sonya Zabludoff, Dennis S. France et al. · Cancer Cell · 2004 · 474 citations · Full text

Transcriptional Coactivation, Transcriptional Regulation, Redox Regulator +9

Psammaplins from the Sponge <i>Pseudoceratina </i><i>p</i><i>urpurea:</i> Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Ivette C. Piña, Jeffrey T. Gautschi, Gui-Yang-Sheng Wang et al. · The Journal of Organic Chemistry · 2003 · 307 citations

Epigenetic Change, Molecular Biology, Dna Methyltransferase +22

<i>N</i>-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2<i>E</i>)-<i>N</i>-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1<i>H</i>-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Stacy Remiszewski, Lidia Sambucetti, Kenneth W. Bair et al. · Journal of Medicinal Chemistry · 2003 · 129 citations · Full text

Pathology, Pharmacotherapy, Pharmaceutical Chemistry +17

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3<i>H</i>-imidazo[4,5-<i>b</i>]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

Jean‐Marc Lapierre, Sudharshan Eathiraj, David Vensel et al. · Journal of Medicinal Chemistry · 2016 · 105 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +18

Discovery and Optimization of a Series of 3-(3-Phenyl-3<i>H</i>-imidazo[4,5-<i>b</i>]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors

Mark A. Ashwell, Jean‐Marc Lapierre, Christopher J. Brassard et al. · Journal of Medicinal Chemistry · 2012 · 98 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Biophysical Screening Strategy +19