Sudharshan Eathiraj

TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism

Xiaojing Pan, Sudharshan Eathiraj, Mary Munson et al. · Nature · 2006 · 342 citations

Gtpase Biology, Biochemistry, Natural Sciences +6

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5

Sudharshan Eathiraj, Xiaojing Pan, C. Ritacco et al. · Nature · 2005 · 239 citations · Full text

Protein Function, Signal Transduction, G Protein-coupled Receptor +6

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

Sean D. Reiff, Rose Mantel, Lisa L. Smith et al. · Cancer Discovery · 2018 · 161 citations · Full text

Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

Sudharshan Eathiraj, Rocio Palma, Erika Volckova et al. · Journal of Biological Chemistry · 2011 · 139 citations · Full text

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092

Yi Yu, Ronald E. Savage, Sudharshan Eathiraj et al. · PLoS ONE · 2015 · 120 citations · Full text

Chemoprevention Strategy, Immunology, Cancer Biology +18