Xiaoke Guo

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Zhengyu Jiang, Mengchen Lu, Lili Xu et al. · Journal of Medicinal Chemistry · 2014 · 252 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Zhengyu Jiang, Lili Xu, Mengchen Lu et al. · Journal of Medicinal Chemistry · 2015 · 88 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5

Dong‐Dong Li, Weilin Chen, Xiaoli Xu et al. · European Journal of Medicinal Chemistry · 2016 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +13

Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Zhengyu Jiang, Hongxi Chu, Meiyang Xi et al. · PLoS ONE · 2013 · 51 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity

Dong‐Dong Li, Weilin Chen, Zhihui Wang et al. · European Journal of Medicinal Chemistry · 2016 · 51 citations · Full text

Medicine, Medicinal Chemistry, Molecular Biology +10