Concepedia

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity

Dong‐Dong Li, Weilin Chen, Zhihui Wang, Xiaoli Xu, Zhengyu Jiang, Xiaojin Zhang, Qidong You, Xiaoke Guo

European Journal of Medicinal Chemistry · 2016 · 51 citations · 21 references

DOIFull text

Open access

Concepts

References

21

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

Thomas A. Milne, Scott Briggs, Hugh W. Brock et al. · Molecular Cell · 2002 · 1.1K citations · Full text

, , +12

Regulation of MLL1 H3K4 methyltransferase activity by its core components

Yali Dou, Thomas A. Milne, Alexander J. Ruthenburg et al. · Nature Structural & Molecular Biology · 2006 · 776 citations

, , +12

Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF

Yali Dou, Thomas A. Milne, Alan J. Tackett et al. · Cell · 2005 · 670 citations · Full text

, , +10

Global and Hox-specific roles for the MLL1 methyltransferase

Matthew G. Guenther, Richard G. Jenner, B. Chevalier et al. · Proceedings of the National Academy of Sciences · 2005 · 356 citations

, , +17

HOXA9 is required for survival in human MLL-rearranged acute leukemias

Joerg Faber, Andrei V. Krivtsov, Matthew C. Stubbs et al. · Blood · 2008 · 330 citations · Full text

, , +7