Victoria Head

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys et al. · Cancer Discovery · 2022 · 134 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

Lisa Rooney, Agnès Vidal, Anne-Marie D’Souza et al. · Journal of Medicinal Chemistry · 2014 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells

Philippa Dale, Victoria Head, Mark R. Dowling et al. · Cell Calcium · 2017 · 22 citations · Full text

Life Sciences, Pharmacology, Physiology +17

Development of autotaxin inhibitors: A series of zinc binding triazoles

Christopher G. Thomson, Darren Le Grand, Mark R. Dowling et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models

Saskia M. Brachmann, Andreas Weiss, Daniel Guthy et al. · Molecular Cancer Therapeutics · 2021 · 10 citations

Medicine, Oncology, Pharmacology +14