Darren Le Grand

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Ian C. Bruce, Mohammed Shahid Akhlaq, Graham C. Bloomfield et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 47 citations · Full text

Signal Transduction, Signaling Pathway, Chemoprevention Strategy +10

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

Cory A. Ocasio, Mohan B. Rajasekaran, Sarah Walker et al. · Oncotarget · 2016 · 39 citations · Full text

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Darren Le Grand, Martin Gosling, Urs Baettig et al. · Journal of Medicinal Chemistry · 2021 · 35 citations · Full text

The Discovery of orally available thrombin inhibitors : Studies towards the optimisation of CGH1668

John Ambler, Emma L. Baker, Lyndon Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 11 citations · Full text

Thrombopoiesis, Thrombosis, Medicinal Chemistry +12

Development of autotaxin inhibitors: A series of zinc binding triazoles

Christopher G. Thomson, Darren Le Grand, Mark R. Dowling et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 11 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Biochemistry +10