Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.1K citations · Full text

Molecular Pharmacology, Metabolic Syndrome, Signal Transduction +14

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 742 citations

Immunology, Immune Regulation, Cell Death +16

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

Sarah E.M. Herman, Amber Gordon, Amy J. Wagner et al. · Blood · 2010 · 541 citations · Full text

Structural insights into phosphoinositide 3-kinase catalysis and signalling

Edward H. Walker, Olga Perišić, Christian Ried et al. · Nature · 1999 · 490 citations

Signal Transduction, Signaling Pathway, Biochemistry +6

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

Alison M. Condliffe · Blood · 2005 · 292 citations · Full text