Shanta Bist

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ann E. Eakin, Oluyinka Green, Neil J. Hales et al. · Antimicrobial Agents and Chemotherapy · 2011 · 132 citations

Essential Enzyme, Lead Identification, Antimicrobial Chemotherapy +18

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian Sherer, Kenneth G. Hull, Oluyinka Green et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 119 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Medicine +10

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

John I. Manchester, Daemian D. Dussault, Jonathan A. Rose et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9

Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents

Gregory S. Basarab, John I. Manchester, Shanta Bist et al. · Journal of Medicinal Chemistry · 2013 · 79 citations · Full text

Bioorganic Chemistry, Antibacterial Activity, Antimicrobial Chemotherapy +24

Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099)

Gregory S. Basarab, Pamela Hill, C. Edwin Garner et al. · Journal of Medicinal Chemistry · 2014 · 78 citations · Full text

Resistance Frequency, Medicinal Chemistry, Bioorganic Chemistry +15