John T. Lazzaro

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

W. M. WELCH, Frank E. Ewing, J. HUANG et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 125 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Jennifer E. Davoren, Che‐Wah Lee, Michelle R. Garnsey et al. · Journal of Medicinal Chemistry · 2016 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors

John McNeish, Marsha L. Roach, John Hambor et al. · Journal of Biological Chemistry · 2010 · 67 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist

John T. Lazzaro, Ana V. Paternain, Juan Lerma et al. · Neuropharmacology · 2002 · 66 citations

Medicine, Neuroscience, Pharmacology +12

Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574

Christopher L. Shaffer, Raymond S Hurst, Renato J. Scialis et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 62 citations

Medicine, Neuroscience, Pharmacology +17