High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

John McNeish, Robert J. Aiello, Deborah J. Guyot, +10

Proceedings of the National Academy of Sciences

GeneticsTangier DiseaseFoam Cell AccumulationLipid MovementCellular Physiology +19

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

Yannick Hamon, Cyril Broccardo, Olivier Chambenoit, +8

Nature Cell Biology

Signal TransductionMedicineApoptosisCell DeathProtein Phosphorylation +8

The Correlation of ATP-binding Cassette 1 mRNA Levels with Cholesterol Efflux from Various Cell Lines

Anna E. Bortnick, George H. Rothblat, Genevieve Stoudt, +4

Journal of Biological Chemistry

Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo

AnhCo Nguyen, Richard Burack, Jeffrey L. Stock, +9

Molecular and Cellular Biology

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

Melanie Allen, Linne Svensson, Marsha L. Roach, +3

The Journal of Experimental Medicine

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Diane Costanzo-Garvey, Paul T. Pfluger, M. K. Dougherty, +23

Cell Metabolism

Metabolic SyndromeInsulin SensitivityEnergy HomeostasisSignal TransductionMolecular Physiology +13

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene.

Bruce J. Aronow, David L. Lattier, Richard Silbiger, +7

Genes & Development

GeneticsMolecular BiologyGene CharacterizationMolecular GeneticsGene Regulatory Network +16

Treatment With Growth Hormone and Dexamethasone in Mice Transgenic for Human Islet Amyloid Polypeptide Causes Islet Amyloidosis and β-Cell Dysfunction

Marta Couce, Laurie A. Kane, Timothy D. O’Brien, +6

Diabetes

Pharma's Developing Interest in Stem Cells

Ruth M. McKernan, John McNeish, D. G. Smith

Cell stem cell

Regenerative MedicineDevelopmental BiologyMedicineAdult Stem CellStem Cell Research +3

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

John McNeish, Jason P. Gardner, Brian J. Wainger, +2

Cell stem cell