Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu, +10

Journal of Clinical Investigation

Tissue EngineeringEngineeringEnhanced CleavageImmunologyType Ii Collagen +20

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

Peter G. Mitchell, Holly A. Magna, Lucy Reeves, +5

Journal of Clinical Investigation

Human Osteoarthritic CartilageType Ii CollagenPathologyOrthopaedic SurgeryInflammatory Arthritis +16

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Clarissa Campbell, Peter T. McKenney, Daniel Konstantinovsky, +12

Nature

Signal TransductionBiliary TractT-regulatory CellImmunologyBacterial Metabolism +8

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Catherine E. Trebino, Jeffrey L. Stock, Colleen P. Gibbons, +16

Proceedings of the National Academy of Sciences

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

Ellen Chuang, Timothy S. Fisher, Rodney Morgan, +7

Immunity

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

Melanie Allen, Linne Svensson, Marsha L. Roach, +3

The Journal of Experimental Medicine

Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases

Romas Geleziunas, Sharon Ferrell, Xin Lin, +7

Molecular and Cellular Biology

Collagenase‐3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by transforming growth factor β

Florina Moldovan, Jean‐Pierre Pelletier, John Hambor, +2

Arthritis & Rheumatism

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Leonard Buckbinder, David T. Crawford, Hong Qi, +20

Proceedings of the National Academy of Sciences

SclerostinCoupled ActionsHigh Bone MassBone FormationOsteoporosis +17

Transferable Immunoglobulin A–Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation

Svetlana Lima, Lasha Gogokhia, Monica Viladomiu, +12

Gastroenterology

DysbiosisMucosal ImmunologyMicrobial PathogensMedicineImmunology +7