Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

Yuji Takebayashi, Philippe Pourquier, Drazen B. Zimonjic, +9

Nature Medicine

Protein FunctionAntiproliferative ActivityNatural SciencesDna ReplicationMolecular Biology +4

Topoisomerase I inhibitors: selectivity and cellular resistance

Yves Pommier, Philippe Pourquier, Yoshimasa Urasaki, +2

Drug Resistance Updates

MedicinePharmacotherapyAnti-cancer AgentPharmacologyInhibitory Activity +3

Induction of topoisomerase I cleavage complexes by 1-β- <scp>d</scp> -arabinofuranosylcytosine (ara-C) <i>in vitro</i> and in ara-C-treated cells

Philippe Pourquier, Yuji Takebayashi, Yoshimasa Urasaki, +3

Proceedings of the National Academy of Sciences

INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity

Asumi Yokota, Shinya Kimura, Satohiro Masuda, +13

Blood

Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.

Yoshimasa Urasaki, Gary S. Laco, Philippe Pourquier, +7

PubMed

Cpt DerivativesCrystal StructureOncogenic AgentMedicineMolecular Biology +12

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

Philippe Pourquier, Jessica L. Waltman, Yoshimasa Urasaki, +4

PubMed

Bioorganic ChemistryTop1 PoisoningMolecular BiologyChemical BiologyEpigenetics +17

Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.

Philippe Pourquier, Christopher Gioffre, Glenda Kohlhagen, +7

PubMed

Collaborative Action of NF-κB and p38 MAPK Is Involved in CpG DNA-Induced IFN-α and Chemokine Production in Human Plasmacytoid Dendritic Cells

Youko Osawa, Sumiko Iho, Rumiko Takauji, +7

The Journal of Immunology

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Olivier Sordet, Qasim A. Khan, Isabelle Plo, +9

Journal of Biological Chemistry

Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression.

Yuji Takebayashi, François Goldwasser, Yoshimasa Urasaki, +2

PubMed

OncologyEt743 Dna AdductsOncogenic AgentMedicineNsc 648766 +12