Shinya Kimura

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

Shinya Kimura, Andrew W. Roberts, Donald Metcalf et al. · Proceedings of the National Academy of Sciences · 1998 · 387 citations

Life Sciences, Cell Biology, Hematology +17

Bim and Bad mediate imatinib-induced killing of Bcr/Abl ⁺ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

Junya Kuroda, Hamsa Puthalakath, Mark S. Cragg et al. · Proceedings of the National Academy of Sciences · 2006 · 333 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial

Jun Imagawa, Hideo Tanaka, Masaya Okada et al. · The Lancet Haematology · 2015 · 300 citations

Medicine, Hematology, Oncology +4

NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

Shinya Kimura, Haruna Naito, Hidekazu Segawa et al. · Blood · 2005 · 244 citations · Full text

Medicine, Oncology, Pharmacology +7

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

Linhua Jin, Yoko Tabe, Sergej Konoplev et al. · Molecular Cancer Therapeutics · 2008 · 204 citations · Full text

Medicine, Hematology, Oncology +15