Gary S. Laco

Topoisomerase I inhibitors: selectivity and cellular resistance

Yves Pommier, Philippe Pourquier, Yoshimasa Urasaki et al. · Drug Resistance Updates · 1999 · 177 citations

Medicine, Pharmacotherapy, Anti-cancer Agent +5

Characterization of the genome of rice tungro bacilliform virus: Comparison with Commelina yellow mottle virus and caulimoviruses

Rongda Qu, Maitrayee Bhattacharyya, Gary S. Laco et al. · Virology · 1991 · 104 citations

Plant Virus, Plant-virus Interaction, Genetics +8

Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

Smitha Antony, Muthusamy Jayaraman, Gary S. Laco et al. · PubMed · 2003 · 102 citations

Chemoprevention Strategy, Molecular Biology, Cpt-resistant Top1 Enzymes +18

Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.

Yoshimasa Urasaki, Gary S. Laco, Philippe Pourquier et al. · PubMed · 2001 · 98 citations

Cpt Derivatives, Crystal Structure, Oncogenic Agent +14

Human Topoisomerase I Inhibition:  Docking Camptothecin and Derivatives into a Structure-Based Active Site Model

Gary S. Laco, Jack Collins, Brian T. Luke et al. · Biochemistry · 2002 · 88 citations