Jean Matthews

Discovery of <i>N</i>-((3<i>R</i>,4<i>R</i>)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1<i>H</i>-pyrazol-4-yl)amino)-9-methyl-9<i>H</i>-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Simon Planken, Douglas C. Behenna, Sajiv K. Nair et al. · Journal of Medicinal Chemistry · 2017 · 90 citations · Full text

Medicine, Oncology, Pharmacology +12

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Michael Siu, Theodore Johnson, Yong Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors

Hengmiao Cheng, Jacqui Hoffman, Phuong Le et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1

Rebecca A. Gallego, Louise Bernier, Hui Chen et al. · Journal of Medicinal Chemistry · 2023 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer

Rebecca A. Gallego, Sujin Cho-Schultz, Matthew Del Bel et al. · Journal of Medicinal Chemistry · 2024 · 19 citations

Pharmacy, Medicinal Chemistry, Oncology +12