Phuong Le

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark P. Jedrychowski et al. · Cell · 2018 · 622 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 585 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows et al. · PubMed · 2003 · 497 citations

Medicine, Oncology, Pharmacology +15

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate

Yi Fan, Jun‐ichi Hanai, Phuong Le et al. · Cell Metabolism · 2017 · 387 citations · Full text

Medicine, Cell Biology, Endocrinology +6

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Yonglong Wei, Yunguan Wang, Yuemeng Jia et al. · Science · 2021 · 283 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +16