Rebecca A. Gallego

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1

Rebecca A. Gallego, Louise Bernier, Hui Chen et al. · Journal of Medicinal Chemistry · 2023 · 33 citations · Full text

Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation

Eric F. Johnson, Michele McTigue, Rebecca A. Gallego et al. · Journal of Biological Chemistry · 2019 · 30 citations · Full text

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

Ted W. Johnson, Rebecca A. Gallego, Alexei Brooun et al. · ACS Medicinal Chemistry Letters · 2018 · 21 citations · Full text

Drug Target, Engineering, Immunology +19

Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer

Rebecca A. Gallego, Sujin Cho-Schultz, Matthew Del Bel et al. · Journal of Medicinal Chemistry · 2024 · 16 citations

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

Ted W. Johnson, Ben Bolaños, Alexei Brooun et al. · ACS Medicinal Chemistry Letters · 2018 · 10 citations