Louise Bernier

Visible‐Light‐Initiated Manganese Catalysis for C−H Alkylation of Heteroarenes: Applications and Mechanistic Studies

Philippe Nuhant, Martins S. Oderinde, Julien Genovino et al. · Angewandte Chemie International Edition · 2017 · 182 citations

Discovery of <i>N</i>-((3<i>R</i>,4<i>R</i>)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1<i>H</i>-pyrazol-4-yl)amino)-9-methyl-9<i>H</i>-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Simon Planken, Douglas C. Behenna, Sajiv K. Nair et al. · Journal of Medicinal Chemistry · 2017 · 89 citations · Full text

Molecular Biology, Wild-type Egfr, Chemical Biology +21

High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Helen A. Clement, Michele Boghi, Rory M. McDonald et al. · Angewandte Chemie International Edition · 2019 · 71 citations

Bioorganic Chemistry, Organic Chemistry, Chemistry +16

Catalytic Enantioselective Synthesis of a <i>cis</i>-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp³–Csp² Cross-Coupling to Access Elusive <i>trans</i>-β-Aryl/Heteroaryl Cyclobutylcarboxyesters

Kévin Nguyen, Helen A. Clement, Louise Bernier et al. · ACS Catalysis · 2020 · 42 citations

Probing the chemical ‘reactome’ with high-throughput experimentation data

Emma King‐Smith, Simon Berritt, Louise Bernier et al. · Nature Chemistry · 2024 · 42 citations · Full text

Engineering, Chemical Analysis, Molecular Biology +16