Concepedia

Jark Böttcher

JB

24

Publications

1.5K

Citations

18

H-Index

2005

Active since

Affiliations

Boehringer Ingelheim (Austria)(Current)

Philipps University of Marburg

Boehringer Ingelheim (Germany)

Bayer (Germany)

Martin Luther University Halle-Wittenberg

Jark Böttcher is an author at Boehringer Ingelheim (Austria) specializing in natural sciences, biochemistry, and molecular biology.

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Publications per year

2005–2023

24

Publications

24

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Dong-Sung Kim, Lorenz Herdeis, Dorothea Rudolph et al. · Nature · 2023 · 448 citations · Full text

The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

Elisabeth V. Schneider, Jark Böttcher, M. Blaesse et al. · Journal of Molecular Biology · 2011 · 142 citations · Full text

Structure–kinetic relationship study of CDK8/CycC specific compounds

Elisabeth V. Schneider, Jark Böttcher, Robert Huber et al. · Proceedings of the National Academy of Sciences · 2013 · 133 citations · Full text

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Jark Böttcher, David Dilworth, Ulrich Reiser et al. · Nature Chemical Biology · 2019 · 101 citations

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS <sup>G12C</sup> Inhibitor

Joachim Bröker, Alex G. Waterson, Chris A. Smethurst et al. · Journal of Medicinal Chemistry · 2022 · 72 citations · Full text

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