Concepedia

Jark Böttcher

JB

Statistics

Publications

25

Citations

1.5K

H-Index

18

Active since

2005

Affiliations

Boehringer Ingelheim (Austria)(Current)

Philipps University of Marburg

Boehringer Ingelheim (Germany)

Bayer (Germany)

Martin Luther University Halle-Wittenberg

Jark Böttcher is an author at Boehringer Ingelheim (Austria) specializing in drug discovery, medicinal chemistry, and structural biology.

Publications per year

2005–2023

25

Publications

25

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Dong-Sung Kim, Lorenz Herdeis, Dorothea Rudolph et al. · Nature · 2023 · 497 citations · Full text

Medicine, Oncology, Pharmacology +17

The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

Elisabeth V. Schneider, Jark Böttcher, M. Blaesse et al. · Journal of Molecular Biology · 2011 · 144 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Structure–kinetic relationship study of CDK8/CycC specific compounds

Elisabeth V. Schneider, Jark Böttcher, Robert Huber et al. · Proceedings of the National Academy of Sciences · 2013 · 136 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Jark Böttcher, David Dilworth, Ulrich Reiser et al. · Nature Chemical Biology · 2019 · 103 citations

Pharmacy, Chemistry, Molecular Biology +16

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS <sup>G12C</sup> Inhibitor

Joachim Bröker, Alex G. Waterson, Chris A. Smethurst et al. · Journal of Medicinal Chemistry · 2022 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

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