Rona K. Graham

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Susan E. Andrew, Y. Paul Goldberg, Berry Kremer et al. · Nature Genetics · 1993 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +12

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

Rona K. Graham, Yu Deng, Elizabeth Slow et al. · Cell · 2006 · 649 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

Y. Paul Goldberg, Donald W. Nicholson, Dita Rasper et al. · Nature Genetics · 1996 · 577 citations

Life Sciences, Biochemistry, Molecular Biology +14

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Austen J. Milnerwood, Clare M. Gladding, Mahmoud A. Pouladi et al. · Neuron · 2010 · 512 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Shu‐ichi Okamoto, Mahmoud A. Pouladi, Maria Talantova et al. · Nature Medicine · 2009 · 431 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12