Ben Powell

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

Skin Cancer, Medicine, Melanoma +7

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 425 citations · Full text

Drug Target, Biochemistry, Medicine +6

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang, Wayne Spevak, Ying Zhang et al. · Nature · 2015 · 374 citations

Signaling Pathway, Medicine, Receptor Tyrosine Kinase +5

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397

Catherine C. Smith, Chao Zhang, Kimberly C. Lin et al. · Cancer Discovery · 2015 · 197 citations · Full text