Brad Hirakawa

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

Yvonne Will, James A. Dykens, Sashi Nadanaciva et al. · Toxicological Sciences · 2008 · 213 citations

Cardiovascular Toxicity, Mitophagy, Mitochondrial Disease +12

First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease

Steven D. Linton, Teresa Aja, Robert A. Armstrong et al. · Journal of Medicinal Chemistry · 2005 · 105 citations

Pathology, Pharmacotherapy, Oxidative Stress +18

Reversible lysine-targeted probes reveal residence time-based kinase selectivity

Tangpo Yang, Adolfo Cuesta, Xiaobo Wan et al. · Nature Chemical Biology · 2022 · 99 citations · Full text

Signal Transduction, Receptor Tyrosine Kinase, Molecular Biology +4

Characterization of IDN-6556 (3-{2-(2-tert-Butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic Acid): a Liver-Targeted Caspase Inhibitor

Niel C. Hoglen, Long-Shiuh Chen, Craig D. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 98 citations

Pan-FGFR Inhibition Leads to Blockade of FGF23 Signaling, Soft Tissue Mineralization, and Cardiovascular Dysfunction

Gina M. Yanochko, Allison Vitsky, Jonathan R. Heyen et al. · Toxicological Sciences · 2013 · 70 citations

Angiogenesis, Bone Morphogenic Protein, Pan-fgfr Inhibition Leads +22