Yuka Takada

A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation In Vivo and Regulates Urethral Tension

Hiroshi Saga, Akira Ohhata, Akio Hayashi et al. · PLoS ONE · 2014 · 57 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

Takaki Komiya, Kazutoyo Sato, Hiroki Shioya et al. · Clinical & Experimental Immunology · 2012 · 49 citations · Full text

Life Sciences, Immunology, Pharmacology +14

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki et al. · Journal of Medicinal Chemistry · 2017 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffold

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia

Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura et al. · ACS Medicinal Chemistry Letters · 2017 · 13 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13