Kazutoyo Sato

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

Takaki Komiya, Kazutoyo Sato, Hiroki Shioya et al. · Clinical & Experimental Immunology · 2012 · 49 citations · Full text

Immunology, Immune Regulation, Immunodominance +20

Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists

Masaki Asada, Tetsuo Obitsu, Atsushi Kinoshita et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 22 citations · Full text

Biochemistry, Medicine, Natural Sciences +9

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: Discovery and exploration of the carboxyamide side chain

Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase et al. · Bioorganic & Medicinal Chemistry · 2009 · 15 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +10

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies

Masaki Asada, Maki Iwahashi, Tetsuo Obitsu et al. · Bioorganic & Medicinal Chemistry · 2010 · 14 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +11