Takaki Komiya

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

Takaki Komiya, Kazutoyo Sato, Hiroki Shioya et al. · Clinical & Experimental Immunology · 2012 · 49 citations · Full text

Life Sciences, Immunology, Pharmacology +14

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki et al. · Journal of Medicinal Chemistry · 2017 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells

Sanzana Hoque, Yuki Kondo, Nodoka Sakata et al. · International Journal of Molecular Sciences · 2020 · 22 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema

Takanori Asakura, Makoto Ishii, Ho Namkoong et al. · Mucosal Immunology · 2018 · 21 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffold

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14