Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Jill Chrencik, C. Roth, Masahiko Terakado, +15

Cell

Crystal StructureBiochemistryG Protein-coupled ReceptorMechanism Of ActionReceptor (Biochemistry) +2

Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis

Yasuaki Sanada, Tsunekazu Mizushima, Yasuyuki Kai, +6

PLoS ONE

ImmunologyGastroenterologyPathologyImmune RegulationTherapeutic Effects +14

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Sujay V. Kharade, H. Kurata, Aaron M. Bender, +13

Molecular Pharmacology

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

Takaki Komiya, Kazutoyo Sato, Hiroki Shioya, +12

Clinical & Experimental Immunology

ImmunologyImmune RegulationImmunodominanceNeurological ProgressImmunologic Mechanism +18

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

Daniel R. Swale, H. Kurata, Sujay V. Kharade, +9

ACS Chemical Neuroscience

Sub-micromolar Pore BlockerHyperpolarization (Biology)Inward Rectifier PotassiumNeurochemistryBiophysics +14

Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges

H. Kurata, Patrick R. Gentry, Masaya Kokubo, +8

Bioorganic & Medicinal Chemistry Letters

EngineeringAerospace EngineeringComputer EngineeringInstrumentationFurther Optimization

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki, +17

Journal of Medicinal Chemistry

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives

Kensuke Kusumi, Koji Shinozaki, Yoshiyuki Yamaura, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOral BioavailabilityPharmaceutical SciencePharmacological StudyBiochemistry +9

Synthesis and Properties of a Series of Phenylene-Bridged Bi<i>_n</i>-Bismuthanes

Yoshihiro Matano, H. Kurata, Toshihiro Murafuji, +2

Organometallics

Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives

Kensuke Kusumi, Koji Shinozaki, Toshiya Kanaji, +7

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryBenzene DerivativesMedicinal ChemistryNatural SciencesMedicine +9