“Catalyst Analogue”: A Concept for Constructing Multicomponent Asymmetric Catalysts (MAC) by Using a Polymer Support

Takayoshi Arai, Tetuya Sekiguti, Kazuhiro Otsuki, +2

Angewandte Chemie International Edition

EngineeringOrganic ChemistryChemistryPolymersChemical Engineering +14

Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

Takaki Komiya, Kazutoyo Sato, Hiroki Shioya, +12

Clinical & Experimental Immunology

ImmunologyImmune RegulationImmunodominanceNeurological ProgressImmunologic Mechanism +18

Compact MR fluid clutch device for human-friendly actuator

Takehito Kikuchi, Ken‐ichi Ikeda, Kazuhiro Otsuki, +2

Journal of Physics Conference Series

EngineeringMechanical EngineeringMechatronicsMechanical SystemsPneumatics +8

Study on the <i>n</i>-alkane patterns in some grasses and factors affecting the <i>n</i>-alkane patterns

Yingjun Zhang, Yasuko Togamura, Kazuhiro Otsuki

The Journal of Agricultural Science

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki, +17

Journal of Medicinal Chemistry

Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives

Kensuke Kusumi, Koji Shinozaki, Yoshiyuki Yamaura, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOral BioavailabilityPharmaceutical SciencePharmacological StudyBiochemistry +9

Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives

Kensuke Kusumi, Koji Shinozaki, Toshiya Kanaji, +7

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryBenzene DerivativesMedicinal ChemistryNatural SciencesMedicine +9

Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives

Kensuke Kusumi, Koji Shinozaki, Yoshiyuki Yamaura, +9

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryBenzene DerivativesMedicinal ChemistryPharmaceutical ChemistryNatural Sciences +8

Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffold

H. Kurata, Kensuke Kusumi, Kazuhiro Otsuki, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineMechanism Of ActionStructure–activity Relationship Studies +3

“Catalyst Analogue”: A Concept for Constructing Multicomponent Asymmetric Catalysts (MAC) by Using a Polymer Support

Takayoshi Arai, Tetuya Sekiguti, Kazuhiro Otsuki, +2

Angewandte Chemie

Materials ScienceChemical EngineeringEngineeringPolymer ScienceHeterogeneous Catalysis +11