Jonathan Larkin

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Kevin S. Thorneloe, Mui Cheung, Weike Bao et al. · Science Translational Medicine · 2012 · 328 citations

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Hongfeng Deng, Heather P. O’Keefe, Christopher P. Davie et al. · Journal of Medicinal Chemistry · 2012 · 147 citations · Full text

Drug Target, Complex Mixtures, Molecular Biology +21

Osteoarthritis endotype discovery via clustering of biochemical marker data

Federico Angelini, Paweł Widera, Ali Mobasheri et al. · Annals of the Rheumatic Diseases · 2022 · 139 citations · Full text

Direct Activation of Protein Kinase C by 1α,25-Dihydroxyvitamin D3

Simon J. Slater, Mary Beth Kelly, Frank J. Taddeo et al. · Journal of Biological Chemistry · 1995 · 127 citations · Full text

Protein Kinase Cα Contains Two Activator Binding Sites That Bind Phorbol Esters and Diacylglycerols with Opposite Affinities

Simon J. Slater, Cojen Ho, Mary Beth Kelly et al. · Journal of Biological Chemistry · 1996 · 116 citations · Full text

Molecular Regulation, Bind Phorbol Esters, Opposite Affinities +18