Maria Wang

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller et al. · Nature Structural & Molecular Biology · 2014 · 499 citations

Molecular Pharmacology, Natural Sciences, Molecular Biology +6

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Mary E. Matyskiela, Suzana S. Couto, Xinde Zheng et al. · Nature Chemical Biology · 2018 · 327 citations

Mutagenesis, Thalidomide-dependent Cereblon Substrate, Biochemistry

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Patrick R. Hagner, Hon‐Wah Man, Celia Fontanillo et al. · Blood · 2015 · 197 citations · Full text

Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN

Chad C. Bjorklund, Jian Kang, Michael Amatangelo et al. · Leukemia · 2019 · 188 citations · Full text

Hematological Malignancy, Dysregulated Crbn, Immunostimulatory Activities +8

Lenalidomide efficacy in activated <scp>B</scp>‐cell‐like subtype diffuse large <scp>B</scp>‐cell lymphoma is dependent upon <scp>IRF</scp>4 and cereblon expression

Ling‐Hua Zhang, Jolanta Kosek, Maria Wang et al. · British Journal of Haematology · 2012 · 170 citations · Full text

Immunology, Immune Regulation, Pathology +17