Franciscus M. H. de Groot

“Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core

Franciscus M. H. de Groot, C. Albrecht, Ralph Koekkoek et al. · Angewandte Chemie International Edition · 2003 · 237 citations · Full text

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 214 citations · Full text

Molecular Biology, Duocarmycin 3B, Pharmaceutical Chemistry +16

Elongated Multiple Electronic Cascade and Cyclization Spacer Systems in Activatible Anticancer Prodrugs for Enhanced Drug Release

Franciscus M. H. de Groot, Walter J. Loos, Ralph Koekkoek et al. · The Journal of Organic Chemistry · 2001 · 117 citations

Combinatorial Chemistry, Novel Spacer Systems, Cyclization Spacer Systems +16

Synthesis and Biological Evaluation of 2‘-Carbamate-Linked and 2‘-Carbonate-Linked Prodrugs of Paclitaxel:  Selective Activation by the Tumor-Associated Protease Plasmin

Franciscus M. H. de Groot, Leon W. A. van Berkom, Hans W. Scheeren · Journal of Medicinal Chemistry · 2000 · 103 citations

Pharmacotherapy, Selective Activation, Pharmaceutical Chemistry +17

Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.

Franciscus M. H. de Groot, Henk J. Broxterman, Hans P. H. M. Adams et al. · PubMed · 2002 · 87 citations

Tumor Biology, Medicinal Chemistry, Tumor-associated Protease Plasmin +14