Ruud G. E. Coumans

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 214 citations · Full text

Molecular Biology, Duocarmycin 3B, Pharmaceutical Chemistry +16

Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

Wim H.A. Dokter, Ruud Ubink, Miranda van der Lee et al. · Molecular Cancer Therapeutics · 2014 · 156 citations · Full text

Drug Target, Immunology, Molecular Biology +18

Synthesis of Porphyrin‐Containing [3]Rotaxanes by Olefin Metathesis

Ruud G. E. Coumans, Johannes A. A. W. Elemans, Pall Thordarson et al. · Angewandte Chemie International Edition · 2003 · 79 citations

Macromolecular Porphyrin Rotaxanes, Engineering, Heterocyclic +10

Processive enzyme mimic: Kinetics and thermodynamics of the threading and sliding process

Ruud G. E. Coumans, Johannes A. A. W. Elemans, Roeland J. M. Nolte et al. · Proceedings of the National Academy of Sciences · 2006 · 68 citations · Full text

Engineering, Synthetic Toroidal Host, Polymers +21

Allosterically Driven Multicomponent Assembly

Pall Thordarson, Ruud G. E. Coumans, Johannes A. A. W. Elemans et al. · Angewandte Chemie International Edition · 2004 · 57 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +17