Ruud G. E. Coumans

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 219 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

Wim H.A. Dokter, Ruud Ubink, Miranda van der Lee et al. · Molecular Cancer Therapeutics · 2014 · 163 citations · Full text

Pharmacy, Oncology, Pharmacology +17

Synthesis of Porphyrin‐Containing [3]Rotaxanes by Olefin Metathesis

Ruud G. E. Coumans, Johannes A. A. W. Elemans, Pall Thordarson et al. · Angewandte Chemie International Edition · 2003 · 79 citations

Natural Sciences, Chemistry, Organic Chemistry +13

Processive enzyme mimic: Kinetics and thermodynamics of the threading and sliding process

Ruud G. E. Coumans, Johannes A. A. W. Elemans, Roeland J. M. Nolte et al. · Proceedings of the National Academy of Sciences · 2006 · 68 citations · Full text

Natural Sciences, Biochemistry, Chemistry +17

Allosterically Driven Multicomponent Assembly

Pall Thordarson, Ruud G. E. Coumans, Johannes A. A. W. Elemans et al. · Angewandte Chemie International Edition · 2004 · 57 citations

Natural Sciences, Biochemistry, Chemistry +9