Concepedia

Synthon (Netherlands)

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Publications

159

Citations

18.5K

Authors

36

Location

Nijmegen, Netherlands

Synthon (Netherlands) is a company institution in Nijmegen, Netherlands known for medicine, engineering, and natural sciences.

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Publications

159

Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study

Udai Banerji, Carla M.L. van Herpen, Cristina Saura et al. · The Lancet Oncology · 2019 · 549 citations · Full text

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“Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core

Franciscus M. H. de Groot, C. Albrecht, Ralph Koekkoek et al. · Angewandte Chemie International Edition · 2003 · 237 citations · Full text

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 214 citations · Full text

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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers

Miranda M.C. van der Lee, Patrick G. Groothuis, Ruud Ubink et al. · Molecular Cancer Therapeutics · 2015 · 208 citations

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Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

Wim H.A. Dokter, Ruud Ubink, Miranda van der Lee et al. · Molecular Cancer Therapeutics · 2014 · 156 citations · Full text

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1–5 of 159

Authors

36

  1. WH
    Wim H.A. Dokter

    Synthon (Netherlands), Netherlands

    120 publications · 1.9K citations

    22

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  2. DE
    David Egging

    Synthon (Netherlands), Netherlands

    38 publications · 1.1K citations

    15

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  3. GV
    Gijs Verheijden

    Synthon (Netherlands), Netherlands

    41 publications · 1.3K citations

    12

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  4. PH
    Patrick H. Beusker

    Synthon (Netherlands), Netherlands

    53 publications · 1.1K citations

    10

    h-index

  5. MT
    Marco Timmers

    Synthon (Netherlands), Netherlands

    26 publications · 491 citations

    6

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1–5 of 36