Wim H.A. Dokter

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985

Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics · 2015 · 214 citations · Full text

Molecular Biology, Duocarmycin 3B, Pharmaceutical Chemistry +16

The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers

Miranda M.C. van der Lee, Patrick G. Groothuis, Ruud Ubink et al. · Molecular Cancer Therapeutics · 2015 · 208 citations

Breast Oncology, Immunology, Pathology +20

Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men

Daniël H. van Raalte, Valentina Nofrate, Mathijs C. Bunck et al. · European Journal of Endocrinology · 2010 · 165 citations · Full text

Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

Wim H.A. Dokter, Ruud Ubink, Miranda van der Lee et al. · Molecular Cancer Therapeutics · 2014 · 156 citations · Full text

Drug Target, Immunology, Molecular Biology +18

Extracellular-Regulated Kinase 1/2, Jun N-Terminal Kinase, and c-Jun Are Involved in NF-κB-Dependent IL-6 Expression in Human Monocytes

Leonore Tuyt, Wim H.A. Dokter, Kim U. Birkenkamp et al. · The Journal of Immunology · 1999 · 124 citations · Full text

Il-6 Secretion, Nf-κb-dependent Il-6 Expression, Immunology +23