Hans W. Scheeren

“Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core

Franciscus M. H. de Groot, C. Albrecht, Ralph Koekkoek et al. · Angewandte Chemie International Edition · 2003 · 237 citations · Full text

Elongated Multiple Electronic Cascade and Cyclization Spacer Systems in Activatible Anticancer Prodrugs for Enhanced Drug Release

Franciscus M. H. de Groot, Walter J. Loos, Ralph Koekkoek et al. · The Journal of Organic Chemistry · 2001 · 117 citations

Combinatorial Chemistry, Novel Spacer Systems, Cyclization Spacer Systems +16

Asymmetric 13-dipolar cycloaddition of nitrones with ketene acetals catalyzed by chiral oxazaborolidines

Jean-Paul G. Seerden, Anita W.A. Schotte op Reimer, Hans W. Scheeren · Tetrahedron Letters · 1994 · 109 citations

Ketene Acetals, Engineering, Heterocyclic +8

Synthesis and Biological Evaluation of 2‘-Carbamate-Linked and 2‘-Carbonate-Linked Prodrugs of Paclitaxel:  Selective Activation by the Tumor-Associated Protease Plasmin

Franciscus M. H. de Groot, Leon W. A. van Berkom, Hans W. Scheeren · Journal of Medicinal Chemistry · 2000 · 103 citations

Pharmacotherapy, Selective Activation, Pharmaceutical Chemistry +17

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Wang Bi, Simon Van Herck, Yong Chen et al. · Journal of the American Chemical Society · 2020 · 93 citations · Full text