Safia Ladha

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt et al. · Acta Neuropathologica Communications · 2018 · 76 citations · Full text

Knockout Mouse, Cell Autophagy, Neurodegenerative Diseases +14

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Bibiana K. Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham et al. · Neurobiology of Disease · 2015 · 55 citations · Full text

Knockout Mouse, Yac128 Mice, Genetic Disorder +9

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

Dagmar E. Ehrnhoefer, Niels H. Skotte, Safia Ladha et al. · Human Molecular Genetics · 2013 · 47 citations

Muscle Tissue, Cell Death, Cellular Physiology +24

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

Dagmar E. Ehrnhoefer, Niels H. Skotte, Jane Savill et al. · PLoS ONE · 2011 · 29 citations · Full text

Immunocytochemical Technique, Immunology, Cell Death +26

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

Dagmar E. Ehrnhoefer, Niels H. Skotte, Jeanette Reinshagen et al. · Cell chemical biology · 2019 · 22 citations · Full text

Mutant Huntingtin Fragment, Protein Function, Signal Transduction +9