Johnson Agniswamy

HIV-1 Protease: Structural Perspectives on Drug Resistance

Irene T. Weber, Johnson Agniswamy · Viruses · 2009 · 153 citations · Full text

Hiv-1 Protease, Antiviral Compound, Medicine +12

HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

Johnson Agniswamy, Chen‐Hsiang Shen, Annie Aniana et al. · Biochemistry · 2012 · 92 citations · Full text

Insight of Host Immune Evasion Mediated by Two Variants of Group A Streptococcus Mac Protein

Johnson Agniswamy, Benfang Lei, James M. Musser et al. · Journal of Biological Chemistry · 2004 · 79 citations · Full text

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Hiv-1 Protease +15

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

Johnson Agniswamy, John M. Louis, Julien Roche et al. · PLoS ONE · 2016 · 51 citations · Full text

Machine Learning, Molecular Biology, Distal Mutations +22