Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Tiffany Wu, Borislav Dejanovic, Vineela Gandham, +18

Cell Reports

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Seung-Hye Lee, William J. Meilandt, Luke Xie, +14

Neuron

Neurodegenerative DiseasesAlzheimer's Diseaseβ-Amyloid PathologyTau AccumulationDegenerative Disease +6

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

Julie A. Di Paolo, Tao Huang, Mercedesz Balázs, +28

Nature Chemical Biology

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseImmune Cell Development +9

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

WeiYu Lin, Daqi Xu, Cary D. Austin, +45

Frontiers in Immunology

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

Eugene Y. Chiang, Ganesh Kolumam, Xin Yu, +17

Nature Medicine

Immune RegulationImmunologyImmunologic MechanismCd4 T Cell ResponsesImmune System +14

Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

Fredric Carlsson, Janice Kim, Calin Dan Dumitru, +4

PLoS Pathogens

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

Yanyan Zheng, Cecile C. de la Cruz, Leanne C. Sayles, +15

Cancer Cell

Lineage PlasticityCell RegulationCd24+itgb4+notchhi CellsMedicineCancer Cell Biology +8

Mouse Models of Rheumatoid Arthritis

Patrick Caplazi, Miriam Baca, Kai Barck, +5

Veterinary Pathology

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Alessia Balestrini, Victory Joseph, Michelle Dourado, +57

The Journal of Experimental Medicine

InflammationAsthmaTrpa1 InhibitorAnti-inflammatoryInflammatory Lung Disease +13

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

Kenneth J. Katschke, Karim Y. Helmy, Micah Steffek, +12

The Journal of Experimental Medicine

Crystal StructureComplement Reverses InflammationComplement PathwaysImmunologyImmunologic Mechanism +22