Eugene Y. Chiang

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

Xin Yu, Kristin Harden, Lino C. Gonzalez et al. · Nature Immunology · 2008 · 1.5K citations

Life Sciences, Cell Biology, Immunology +15

Peripheral T cell expansion predicts tumour infiltration and clinical response

Thomas D. Wu, Shravan Madireddi, Patrícia E. de Almeida et al. · Nature · 2020 · 795 citations

Life Sciences, Immunology, Oncology +16

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre et al. · Immunity · 2022 · 347 citations · Full text

Medicine, Immunology, Pharmacology +17

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

Eugene Y. Chiang, Ganesh Kolumam, Xin Yu et al. · Nature Medicine · 2009 · 185 citations

Life Sciences, Immunology, Pathology +16

Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells

Xiangnan Guan, Ruozhen Hu, Yoonha Choi et al. · Nature · 2024 · 123 citations · Full text

Medicine, Immunology, Oncology +17