Xiangnan Guan

Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data

Duanchen Sun, Xiangnan Guan, Amy E. Moran et al. · Nature Biotechnology · 2021 · 518 citations · Full text

Life Sciences, Bioinformatics, Cell Biology +14

Androgen receptor activity in T cells limits checkpoint blockade efficacy

Xiangnan Guan, Fanny Polesso, Chaojie Wang et al. · Nature · 2022 · 393 citations · Full text

Life Sciences, Immunology, Oncology +16

Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance

Joshi J. Alumkal, Duanchen Sun, Eric Lu et al. · Proceedings of the National Academy of Sciences · 2020 · 169 citations · Full text

Medicine, Oncology, Pharmacology +17

Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer

William S. Chen, Rahul Aggarwal, Li Zhang et al. · European Urology · 2019 · 141 citations · Full text

Medicine, Molecular Genetics, Oncology +17

The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Andrew Chow, Fathema Uddin, Michael Liu et al. · Immunity · 2022 · 126 citations · Full text

Life Sciences, Immunology, Oncology +17