Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Kenneth H. Huang, James M. Veal, R. Patrick Fadden, +29

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyChemical BiologyNovel 2-Aminobenzamide InhibitorsMedicinal Chemistry +14

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Thomas E. Barta, James M. Veal, John W. Rice, +11

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryDrug TargetBiochemistryNatural Sciences +8

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal, +26

Chemistry & Biology

Drug TargetMedicineNatural SciencesProteomicsBiomarker Target +6

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for<i>PPARG</i>Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

Briana Foley, Daniel Doheny, Michael B. Black, +5

Toxicological Sciences

Metabolic DisorderMetabolic RemodelingStem Cell BiologyAdipokinesInsulin Signaling +21

The Use of High-Content Screening for the Discovery and Characterization of Compounds That Modulate Mitotic Index and Cell Cycle Progression by Differing Mechanisms of Action

Amy F. Barabasz, Briana Foley, James Otto, +2

Assay and Drug Development Technologies

Targeting of Multiple Signaling Pathways by the Hsp90 Inhibitor SNX-2112 in EGFR Resistance Models as a Single Agent or in Combination With Erlotinib

John W. Rice, James M. Veal, Amy F. Barabasz, +6

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Chemoprevention StrategyProlonged Animal SurvivalTumor BiologyHsp90 Inhibitor Snx-2112Signaling Pathway +16

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

Saad Haider, Michael B. Black, Bethany Parks, +6

Frontiers in Pharmacology

Novel carbazole and acyl-indole antimitotics

Thomas E. Barta, Amy F. Barabasz, Briana Foley, +7

Bioorganic & Medicinal Chemistry Letters

Novel CarbazoleMedicinal ChemistryAntibacterial AgentAntimicrobial CompoundPharmacology +2

20α-Hydroxysteroid Dehydrogenase Activity in the Rabbit Ovary

Jerome F. Strauss, Briana Foley, Richard Stambaugh

Biology of Reproduction

Human GrowthGynecologyFemale Reproductive FunctionReproductive BiologyRabbit Ovary +19

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Kenneth H. Huang, Thomas E. Barta, John W. Rice, +14

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryHeat ShockMedicine +6