Francis Bourbonais

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Han Dai, April Case, Thomas V. Riera et al. · Nature Communications · 2015 · 203 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells

Matthew Brady, Francis Bourbonais, Alan R. Saltiel · Journal of Biological Chemistry · 1998 · 122 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield et al. · Journal of Medicinal Chemistry · 2011 · 115 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · Full text

Life Sciences, Biochemistry, Pharmacology +10

Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene

Audrey F. Seasholtz, Francis Bourbonais, C E Harnden et al. · Molecular and Cellular Neuroscience · 1991 · 52 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14