Kam Y. J. Zhang

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

Skin Cancer, Medicine, Melanoma +7

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Germline KRAS mutations cause Noonan syndrome

Suzanne Schubbert, Martin Zenker, Sara L. Rowe et al. · Nature Genetics · 2006 · 736 citations

Germline Kras Mutations, Mendelian Disorder, Genetic Disorder +6

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

Shie-Pon Tzung, Kristine M. Kim, Gorka Basáñez et al. · Nature Cell Biology · 2001 · 448 citations

Antibiotic Adjuvant, Apoptosis, Cell Death +7

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 425 citations · Full text

Drug Target, Biochemistry, Medicine +6