Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

Roger P.M. Sutmuller, Leonie M. van Duivenvoorde, Andrea van Elsas, +6

The Journal of Experimental Medicine

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

Andrea van Elsas, Arthur A. Hurwitz, James P. Allison

The Journal of Experimental Medicine

ImmunologyImmunodominanceImmunologic MechanismImmunotherapeuticsTumor Cell Vaccine +23

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

Burkhard Jansen, Hermine Schlagbauer‐Wadl, Bob D. Brown, +6

Nature Medicine

MelanomaScid MiceImmune Checkpoint InhibitorImmunotherapyMedicine +3

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Kelsey E. Sivick, Anthony L. Desbien, Laura Hix Glickman, +22

Cell Reports

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Yu‐Tzu Tai, Chirag Acharya, Gang An, +12

Blood

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

Andrea van Elsas, Roger P.M. Sutmuller, Arthur A. Hurwitz, +8

The Journal of Experimental Medicine

ImmunologyB16 Melanoma VaccineImmunologic MechanismAntigen ProcessingImmunotherapeutics +17

CD47–signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction

Xi Zhao, Ellen M. van Beek, Karin Schornagel, +12

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationCell DeathImmunologic MechanismImmunotherapy +14

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Bram Priem, Mandy M. T. van Leent, Abraham J. P. Teunissen, +42

Cell

Tumor ImmunologyCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +10

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.

Andrea van Elsas, Shuraila F. Zerp, S. van der Flier, +5

PubMed

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Raoul Frijters, Wilco Fleuren, Erik J. M. Toonen, +8

BMC Genomics