Bob D. Brown

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

Burkhard Jansen, Hermine Schlagbauer‐Wadl, Bob D. Brown et al. · Nature Medicine · 1998 · 487 citations

Melanoma, Scid Mice, Immune Checkpoint Inhibitor +5

Localization of specific mRNAs in <i>Xenopus</i> embryos by whole-mount <i>in situ</i> hybridization

Ali Hemmati‐Brivanlou, Dale Frank, Margaret E. Bolce et al. · Development · 1990 · 324 citations

RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

Shanthi Ganesh, Xue Shui, Kevin P. Craig et al. · Molecular Therapy · 2018 · 120 citations · Full text

Antitumor Activity, Immunology, Immunotherapeutics +18

Safety and activity of DCR-MYC, a first-in-class Dicer-substrate small interfering RNA (DsiRNA) targeting MYC, in a phase I study in patients with advanced solid tumors.

Anthony W. Tolcher, Kyriakos P. Papadopoulos, Amita Patnaik et al. · Journal of Clinical Oncology · 2015 · 116 citations

Engineering, Synthetic Dsirna, Pathology +21

Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria

Cheng-Jung Lai, Natalie W. Pursell, Jessica J. Gierut et al. · Molecular Therapy · 2018 · 104 citations · Full text